Category: fofabvlic

Reports detail experimental Ebola treatment, virus evolution

first_imgMedical teams yesterday described their experience treating two sick US health workers with TKM-Ebola and convalescent serum, while another group that looked at genetic sequences from Liberian Ebola patient reported that changes in the virus so far don’t appear to affect diagnosis and experimental treatments.Investigators published their findings in Clinical Infectious Diseases and Emerging Infectious Diseases, respectively.First use of experimental comboThe first study involved two US physicians who were evacuated from the outbreak region after they were infected with Ebola. Rick Sacra, MD, was flown to the high-biocontainment unit at Nebraska Medical Center in Sep 5 after he was infected in Liberia, and Ian Crozier, MD, was admitted to Emory University Hospital’s special communicable disease unit on Sep 9 after he was infected in Sierra Leone.Sacra is a family medicine physician from the University of Massachusetts Medical School who was working for the missionary group SIM USA, and Crozier is an infectious disease specialist from Vanderbilt University who was working for the World Health Organization (WHO).Both patients received aggressive supportive care, and their clinicians got clearance and patient consent to use two experimental treatments: TKM-Ebola, a short-strand RNA (siRNA) drug cocktail developed by Tekmira Pharmaceuticals, and convalescent serum.Sacra received his first of seven daily TKM-Ebola infusions on day 8 of his illness. He experienced fever and chills after his first three treatments with the drug and chills on the final day. He received 1 liter of type-specific convalescent plasma from a recovered patient in two 500-milliliter (mL) transfusions on days 9 and 10 of his illness with no sign of transfusion reaction.He recovered and was discharged from the hospital on day 28 of his illness.Crozier was given his first TKM-Ebola infusion on day 3 of his illness before his medical evacuation, and he continued to receive it after he was admitted to Emory. His medical team discontinued the medication after the fifth dose, however, because clinicians worried that it might have been contributing to his deteriorating medical condition, which included worsening acidosis, atrial fibrillation, and kidney problems.He received six 500-mL doses of convalescent plasma on days 8, 9, 11, 12, 14, and 15 of his illness. Crozier’s shortness of breath worsened after his first transfusion, and he needed oxygen, which required intubation. His condition slowly improved, and he was extubated on day 21.After recovery, he was discharged from Emory on day 44 of his illness.Unclear if treatments helpedClinicians who treated both patients said it’s unknown if uncontrolled use of experimental treatments helped the two survivors, and they noted that aggressive supportive care probably contributed to their recovery. They linked Crozier’s deteriorating condition to his Ebola infection, but said it’s impossible to exclude the role of the experimental treatments.They noted that clinical studies so far haven’t shown any serious adverse effects and that the fever and chills Sacra experienced aren’t unexpected with siRNA treatment.  They said, though, that future studies on siRNA products should explore the possibility of adverse effects from immune activation.Also unclear is whether Ebola immunoglobulins or other plasma components in convalescent serum played any role in the recovery of the two doctors, the team wrote, emphasizing that controlled trials are needed to gauge the effects on the clinical course of the disease.A trial of TKM-Ebola launched in March in Sierra Leone, and trials of convalescent plasma therapy are also under way in the outbreak countries.Real-time Ebola sequencing in LiberiaThe gene-sequencing study was conducted with advanced capabilities provided by a consortium by the US government and nongovernmental agencies to help Liberia’s government with Ebola surveillance. The group has equipped the Liberian Institute for Biomedical Research with a Miseq sequencer.The team of US and Liberian researchers described their analysis of 25 genomes from samples collected from September 2014 through February 2015.They noted that the findings suggest a single introduction of the virus into Liberia, but a comparison with other isolates from the region showed a relationship to Ebola virus from Mali, hinting at movement of the virus across Liberia’s border at least once.Though viruses showed diversification in Liberia, researchers found nothing unusual with the pace of the virus changes.The group found 23 nonsynonymous mutations and 1 nonsense mutation that haven’t been seen before in West Africa, but they said more study is needed to determine if they affect viral fitness. Five of the mutations they found might affect a component of ZMapp binding, but the changes were seen at low levels, they reported. The team didn’t find any changes that would impair the diagnostic tests that Liberia uses for Ebola.Case total update, test kit recallThe WHO said today that the number of confirmed, probable, and suspected Ebola infections in the three affected countries has edged up to 26,074, with the number of deaths reaching 10,820. The totals reflect an increase of 30 cases and 12 deaths since the WHO’s update yesterday. Today’s numbers include data from Guinea and Sierra Leone as of Apr 21 and Liberia as of Apr 19.The US Food and Drug Administration (FDA) today announced that LuSys Laboratories, based in San Diego, has recalled its Ebola Virus One-Step Test Kits, because they are not cleared for marketing. It said the devices were sold in California and exported to Sierra Leone, Canada, and Denmark between October 2014 and January 2015. It said the devices don’t have emergency use authorization clearance. The agency said the tests haven’t been cleared for use or sale and that results obtained from the kits haven’t shown to be accurate. False-positives or false-negatives could be life threatening, the FDA said. LuSys initiated a product recall on Mar 13.See also:Apr 22 Clin Infect Dis abstractApr 22 Emerg Infect Dis reportApr 23 WHO updateApr 23 FDA recall noticelast_img read more

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News Scan for Aug 06, 2019

first_imgDRC Ebola outbreak grows by 11; GSK stops Ebola vaccine workThe Democratic Republic of the Congo (DRC) ministry of health will likely record 11 more cases of Ebola today, raising the outbreak total to 2,774, including 1,849 deaths. The death toll has grown by 6 since yesterday.All outbreak numbers come from the World Health Organization’s (WHO’s) online Ebola dashboard. DRC officials have not released any reports on the outbreak since Aug 2.In other Ebola news, British pharmaceutical giant GlaxoSmithKline (GSK) is stopping work on two Ebola vaccine candidates and a Marburg vaccine candidate and giving exclusive technology license to the Sabin Vaccine Institute in Washington, D.C, GSK said in a news release today.”These agreements with the Sabin Vaccine Institute are an important next step in the fight against Ebola and Marburg viruses,” said Thomas Breuer, MD, GSK’s chief medical officer. “Enabling Sabin to build on the scientific progress GSK has delivered up to Phase II [trials] increases the likelihood these candidate vaccines may help prevent potential future outbreaks, and exemplifies GSK’s approach to global health vaccines which supports partners in taking forward our innovations in a sustainable way.”One of the Ebola candidates, ChAd3 Ebola Zaire, has been through mid-stage phase 2 trials in Africa. All three vaccines, collectively known as the ChAd3 vaccines, have been shown to be safe in human trials.”Sabin plans to continue the development and seek regulatory approval of Ebola and Marburg vaccines with our shared goal of making them available to the millions of people potentially at risk,” said Sabin CEO Amy Finan. WHO online Ebola dashboard Aug 6 GSK press release Study finds antibiotics used for noninfectious indications in kidsA point-prevalence study of US children’s hospitals found that 1.7% of hospitalized pediatric patients received at least one antibiotic for a noninfectious indication, a team of US researchers reported in the Journal of the Pediatric Infectious Diseases Society.In the cross-sectional study of 32 academic tertiary-care pediatric inpatient facilities, conducted from June 2016 through December 2017, researchers reviewed a total of 35,378 patient records and identified 13,215 patients (37.3%) who received at least one antimicrobial agent. Among those who received an antibiotic were 627 patients (1.7% of all admitted patients) who had a noninfectious indication. Antibiotic use for a noninfectious indication among patients who received an antibiotic ranged from 0% to 10.1% across the hospitals.Of the twenty-nine unique antibiotics used for a noninfectious indication, the most commonly prescribed antibiotics were erythromycin (63.1%), azithromycin (19.9%), amoxicillin-clavulanate (5.5%), and metronidazole (5.2%). The most common reason for antibiotic use was gastrointestinal prokinesis (67.4%), followed by use for anti-inflammatory properties (17.5%) and small-bowel bacterial overgrowth (5.5%).The authors of the study say the lack of national consensus guidelines for aiding decisions about when to use antibiotics for noninfectious indications makes it difficult to assess whether these prescriptions were appropriate. They also note that data are limited on whether these agents are effective for treating the noninfectious indications documented in the study, or on how their use in children affects the intestinal microbiome.They conclude, “Multidisciplinary efforts should be taken to carefully analyze the effectiveness of these agents for their intended purpose while considering the effect on the pediatric microbiome, the harms of antimicrobials, and the potential societal effects of antimicrobial resistance within the community. Antimicrobial stewards should partner with those in other disciplines to understand and improve research into these longer-term harms.”Jul 31 J Pediatric Infect Dis Soc study DRC measles outbreak grows as Central African Republic reports casesAccording to the WHO’s African regional office, both the DRC and Central African Republic (CAR) report ongoing measles outbreaks, with the DRC’s growing rapidly.Since the last report in June, 54 more health zones in the DRC have recorded transmission rates reaching the epidemic phase. From Jan 1 through Jul 21, the DRC has seen a total of 137,154 suspected measles cases, including 2,581 deaths (case-fatality rate, 1.9%). Cases have been increasing since Jul 7.”Children less than five years old are the most affected, accounting for 77% of all reported cases and 90% of measles-associated deaths. Most (63%) of the cases had not been previously vaccinated or had unknown vaccination status,” the WHO said.Both Ituri and North Kivu provinces, the site of the DRC’s ongoing Ebola crisis, are affected in the outbreak. North Kivu province is averaging 123 measles cases per week in the past 5 weeks, while Ituri is averaging 196 cases per week.DRC has low vaccination coverage, with only 57% of the population covered by one dose of the measles, mumps, and rubella (MMR) vaccine in 2018.In the CAR, the WHO reported another 12 cases of measles, bringing the outbreak total to 278 suspected cases, including 2 deaths, since earlier this summer. This is the eighth measles outbreak in the country since 2016. Vaccination coverage with one dose of MMR vaccine is even lower in the CAR than in the DRC, hovering around 48%. Aug 4 WHO African regional bulletin Philippines declares dengue epidemicThe Philippines has declared a dengue epidemic, as the country has recorded more than 146,000 cases and 622 deaths so far this year.The case counts in 2019 represent a 98% increase from case counts in 2018, according to The South China Morning Post.The declaration of an epidemic allows the government to use emergency funds to control the virus, which is spread by mosquitoes and is endemic in the Philippines.The Philippines has struggled with dengue in the past, and was one of the first countries to launch a national vaccination campaign with Dengvaxia, Sanofi Pasteur’s dengue vaccine. But that campaign ended in 2017 when scientists connected vaccine use to several pediatric deaths from severe dengue in those who had not previously been exposed to the disease.According to the story, several other countries in South and Southeast Asia are also seeing high dengue levels this summer, including Malaysia, Vietnam, and Bangladesh. Aug 6 South China Morning Post story Kineta receives more Wellcome Trust support for Lassa drug trialsKineta, a Seattle-based biotechnology company, today reported that it has received $1.8 million more from the Wellcome Trust for further testing of its once-daily antiviral drug LHF-535 for treating Lassa fever.In a statement, the company said the award was based on promising phase 1a clinical trial results in healthy volunteers and that the new support will fund the phase 1b multiple ascending dose clinical trial and position LHF-535 for a phase 2 study in Lassa fever patients where no approved treatment is available.Wellcome Trust awarded Kineta up to $7.2 million in 2016 to support the development of the Lassa fever treatment. In the phase 1a study, 48 volunteers across six cohorts received either a single oral dose of placebo or LHF-535 across six dose levels, ranging from .03 to 40 milligrams per kilogram of body weight. Researchers found that the drug was safe and well tolerated, with the frequency of adverse events similar to placebo.The phase 1b trails is slated to begin in the third quarter of 2019. Earlier this year, Kineta announced that it had received up to $5.8 million from the National Institute of Allergy and Infectious Diseases to explore possible arenavirus indications for LHF-535.Aug 6 Kineta press releaselast_img read more

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BOC sponsors a helium project

first_imgGet instant access to must-read content today!To access hundreds of features, subscribe today! At a time when the world is forced to go digital more than ever before just to stay connected, discover the in-depth content our subscribers receive every month by subscribing to gasworld.Don’t just stay connected, stay at the forefront – join gasworld and become a subscriber to access all of our must-read content online from just $270. Subscribelast_img

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Shell hit by another round of Arctic drilling protests

first_imgTwo activists have secured themselves to the anchor chain of the vessel that is part of Shell’s Arctic-bound fleet docked in Bellingham, Washington on Friday morning, June 12, 2015. According to the U. S. Coast Guard, watchstanders at Sector Puget Sound received a call around 4:50 a.m., from Station Bellingham personnel, reporting protesters had secured themselves to the Shell-contracted vessel’s chain.The Coast Guard established a 100-yard safety zone in place around Arctic drilling and support vessels while moored or anchored, and a 500-yard safety zone while those vessels are transiting.About five hours later, the Coast Guard boatcrew assisted Bellingham Police Department personnel in the removal of those two activists secured to the chain of the barge American Trader.The protesters were taken to Coast Guard Station Bellingham at about 9:30 a.m., aboard a 45-foot Response Boat-Medium, where Bellingham Police officers placed them under arrest. According to the press statement, Coast Guard Sector Puget Sound investigating officers intend to issue a notice of violation.“Coast Guard personnel have an excellent working relationship with our partner law enforcement agencies, and together we are committed to the safety of life at sea,” said Lt. Cmdr. Justin Noggle, chief of enforcement at Sector Puget Sound.“We will continue to enforce those laws and regulations necessary to ensure the safety of the maritime public.”Safety zone violations can result in a maximum civil penalty of $40,000 for each entry into the zone or day the individuals violated the zone.This is the second time that one of Shell-contracted vessels, that is part of its Arctic drilling fleet, has been a target for activists protesting Shell’s Arctic drilling plans. The previous attempt also included two activists that chained themselves to Shell’s support vessel Arctic Challenger. The U. S. Coast Guard Sector Puget Sound investigating officers later on initiated civil penalties against four individuals who entered an established safety-zone around the Arctic Challenger including the two who were secured on the anchor chain.last_img read more

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ACS flies in first relief to Yemen

first_imgACS ceo Justin Bowman stated that the company used an IL-76 aircraft to fly aid in last Thursday, on behalf of one of the governments working with the Gulf Cooperation Council. The aircraft was carrying 35 tonnes of food stuffs and medical supplies, as well as six diplomats.www.aircharterservice.comlast_img

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LR to classify Heerema crane vessel

first_imgThe semi-submersible vessel will be equipped with two tub-mounted 10,000 tonne capacity cranes from Huisman. The dual-fuel LNG and MGO vessel is scheduled for delivery in the fourth quarter of 2018, and will be used in the installation and decommissioning of offshore facilities. It will also come equipped with dynamic positioning capabilities in excess of the DP (AAA) standard. The vessel will be built at Sembcorp’s ‘Mega Yard’ in Singapore.In total, the NSCV project will cost in the region of USD1 billion, says LR. Compliance with a range of coastal state requirements including Norwegian Maritime Authority (NMA), UK and USCG regulations means it will be capable of deep and ultra-deep sea operations on a global scale. Jan-Pieter Klaver, ceo of Heerema Marine Contractors, said: “Our contract with Jurong Shipyard represents the next critical step in our plans to introduce the NSCV to the market. The fact that we decided to press on with our plans in these times of low oil prices, shows our belief in the offshore oil and gas industry and demonstrates our continued commitment to offer unparalleled installation services to the industry.” Piet Mast, LR’s marine area manager for South Asia, said that this as the next step in a long-running partnership between the Heerema Group and LR. “The Heerema Group is demonstrating its commitment to the marine and offshore industry.  With the opening of LR’s new Global Technology Centre in Southampton this complex project is a good fit for LR and is an exciting challenge for the LR team in Singapore who are supported by a range of LR global experts.”  www.lr.orgwww.heerema.nllast_img read more

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Challenge legal aid contract decisions quickly, solicitors warned

first_imgAny challenges to the government’s awards of new legal aid contracts must be done quickly, anxious criminal defence solicitors were warned last night.Firms will shortly discover via the Legal Aid Agency’s Bravo e-tendering portal whether they have been successful with bids for a reduced number of contracts to provide 24-hour cover at police stations.A spokesperson for the agency told the Gazette that applicant organisations would be notified about the tender outcomes ‘this week’.’We will make an announcement when we start to notify organisations about the outcome of their bid,’ the spokesperson said.’All new contracts will start in January 2016 in line with the planned timetable.’All firms will be notified of the tender outcome on the same day, the Gazette understands.On Monday, the Law Society set out guidance on potential routes for challenging the LAA’s decisions.Last night London firm Bindmans held a seminar to help solicitors understand their options for challenging contract decisions.Public law barrister Joanne Clement, of London-based chambers 11KBW, told solicitors they ‘have to act quickly and, in reality, before the LAA or MoJ enters into a contract with successful bidders’.According to the LAA’s information for applicants document, contract execution and start dates are scheduled to be made the week commencing 5 October.Clement said successful bidders’ award letters should contain the date on which the ministry intends to enter into an agreement.‘If not, that’s the very first thing you need to know because you need to issue any claim before that happens,’ she said.11KBW’s Jason Coppel QC told the seminar that claims in procurement cases were ‘very often’ issued ‘before you really know how strong your case is’.Coppel said there was a ‘whole series of extra information’ firms need to obtain through correspondence with the LAA to help them understand whether or not they have grounds for a ‘proper’ challenge.‘Some of that will be given willingly, some not,’ he said.Meanwhile shadow solicitor general Karl Turner has written to lord chancellor Michael Gove urging him to delay the rollout of the ministry’s two-tier contract reforms.Service under the new contracts is scheduled to commence on 11 January.‘I urge you to push back the timetable for these damaging proposals,’ the Hull MP wrote. ‘At least until proper consideration is given to alternatives offered by the respective practitioner groups.’last_img read more

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UWF football 1-day camp on July 14 to feature former NFL star Fred Robbins

first_img Share Fred Robbins playing with the St. Louis Rams (Photo by G. Newman Lowrance, AP) UWF football 1-day camp on July 14 to feature former NFL star Fred Robbinscenter_img PENSACOLA, Fla. – The University of West Florida football coaching staff will host its first camp on Monday, July 14 at the intramural field on the main UWF campus, and former NFL star Fred Robbins will be one of many guest coaches. The camp will be open to upcoming high school juniors and seniors and will cost $50 per participant.Walk-up registrations will be accepted, and participants are asked to bring the completed registration and waiver forms with them on Monday with the $50 fee. Check-in will begin at 8 a.m., and the camp will begin at 9 a.m.Fred Robbins is a Pensacola native and a graduate of Tate High School. He played football at Wake Forest from 1996 to 1999, where he was a teammate of current UWF offensive coordinator and wide receivers coach Jammie Deese. Robbins, a defensive lineman, was a second round pick by the Minnesota Vikings in the 2000 NFL Draft. He played 12 seasons in the NFL with the Vikings, New York Giants and St. Louis Rams, and he was on the Giants’ 2008 team that won Super Bowl XLII.The University of West Florida Department of Intercollegiate Athletics has won seven national championships, and UWF leads all schools in Gulf South Conference history with 79 league championships and 18 all-sports trophies. Football will be the 15th varsity sport at the University. UWF President Judy Bense confirmed on Sept. 4, 2013 that the team will begin playing in 2016, and the University reached an agreement in concept for the team to play its home games at Maritime Park Stadium in downtown Pensacola starting that fall.For information on all UWF athletics, visit www.GoArgos.com.#ARGOS#Registration Form Waiver FormPrint Friendly Versionlast_img read more

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Layanan Ride-Hailing Dilarang, DeNA Luncurkan Taksi Gratis yang Hubungkan 23 Kota Besar di Jepang

first_imgSumber: asia.nikkei.com Mungkin sebagian dari Anda masih ingat dengan DeNa, sebuah perusahaan teknologi yang berfokus pada e-commerce dan entertain yang sempat terbentur masalah regulasi dalam upayanya untuk merilis bus otonom pada pertengahan tahun 2017 silam. Kini perusahaan yang berbasis di Tokyo, Jepang tersebut dikabarkan baru saja menyelesaikan campaign yang bertujuan untuk mengejar ketertinggalan mereka dengan perusahaan sejenis di negara penghasil komik manga tersebut.Baca Juga: Hadirkan Bus Otonom, DeNA Terbentur Regulasi Tentang Bangku PengemudiSebagaimana yang dikutip KabarPenumpang.com dari laman asia.nikkei.com (6/12/2018), perusahaan ini menyediakan sejumlah armada yang dapat digunakan oleh penumpang secara cuma-cuma alias gratis dalam periode waktu dan wilayah tertentu. Tidak berdiri sendiri, sebanyak 50 armada cab-hailing milik DeNA yang dikerahkan untuk mengoperasikan campaign ini berbalut ‘livery’ dari sponsor mereka, yaitu Nissin Foods Holdings. Untuk ongkos yang seharusnya dikenakan kepada penumpang nantinya akan dibayar oleh pihak DeNa dan Nissin Foods Holdings sendiri. Seperti yang sudah disebutkan di atas, wilayah penjemputan taksi berbalut iklan mie instan ini hanya berada di sekitar pusat kota Tokyo namun dapat mengantarkan penumpang hingga ke lebih dari 23 kota besar di Jepang.Sejak diberlakukannya pelarangan terhadap kendaraan pribadi yang digunakan untuk layanan ride-hailing, makin banyak perusahaan yang berusaha untuk mencari langkah inovatif guna meminimalisir penggunaan kendaraan pribadi di jalanan.Campaign ini sendiri tidak berhenti sampai di sini. DeNa diketahui tengah mematangkan beberapa konsep mereka, seperti menjalin kerja sama baru dengan berbagai sponsor, pengaturan armada jika ada seseorang yang telah mereservasi restoran, hingga sinkronisasi dengan jadwal bepergian para pengguna jasanya.“Campaign ini dapat menghubungkan orang-orang yang jarang sekali menggunakan fasilitas taksi,” ujar Hiroshi Nakajima, Kepala Bisnis Otomotif DeNa.“Selain itu, operator taksi juga dapat mengharapkan sumber pendapatan yang dapat diandalkan,” imbuh Hiroshi.Sistematika dari layanan taksi gratis ini seyogyanya sama persis dengan layanan ride-hailing lain, dimana penumpang hanya perlu menentukan titik penjemputan, memilih lokasi tujuan, dan segala informasi yang terkait dengan perjalanan tersebut akan terpampang di aplikasi yang harus terlebih dahulu dimiliki oleh penumpang.Baca Juga: Sering Tertukar, Ini Dia Perbedaan Antara Ride-Sharing dan Ride-HailingRencananya, pada paruh kedua tahun 2019, DeNA akan menampilkan sejumlah fitur baru yang ditujukan untuk meningkatkan kenyamanan dan pengalaman penumpang selama berkendara, seperti rute terbaik yang dapat ditempuh.Seperti yang sudah kita ketahui bersama, layanan ride-hailing atau ride-sharing merupakan moda transportasi first and last mile yang dapat diandalkan penumpang sebagai moda pengumpan untuk moda transportasi berbasis massal. Namun dengan dilarangnya pengoperasian dari moda jenis ini di Jepang, maka wajar saja jika banyak perusahaan layanan transportasi yang mengupayakan untuk tetap memberikan layanan prima kepada para penumpangnya. Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)Like this:Like Loading… RelatedTidak Ada Layanan Ride-Hailing, Inikah Masa Kejayaan Taksi di Jepang?09/01/2019In “Basis Aplikasi”Hadirkan Bus Otonom, DeNA Terbentur Regulasi Tentang Bangku Pengemudi30/08/2017In “Darat”S.Ride, Aplikasi dari Sony untuk Taksi Hailing di Jepang20/04/2019In “Basis Aplikasi”last_img read more

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Chelsea offer Tottenham £50 million for Danny Rose

first_imgPremier League champions, Chelsea are plotting to make Tottenham a £50 million offer for left-back Danny Rose.Tottenham will tackle the Blues at the weekend in a London derby at Wembley.The Sun UK reports that the England international, who complain about his low wages compared to players at other clubs inside the top six, will cost Chelsea £50 million.The news is likely to put an end to Chelsea’s summer long pursuit of Alex Sandro.Juventus are not willing to sale the Brazilian after selling star centre-back Leonardo Bonucci to AC Milan which has pushed the Blues to consider Rose as an alternative in search of competition for Marcos Alonso at left wing-back.last_img read more

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